Endocrine Abstracts

Introduction: Tolvaptan is an oral vasopressin V2 receptor antagonist which offers a novel treatment for euvolaemic and hypervolaemic hyponatraemia. Here, we report our experience with Tolvaptan in elderly patients.Case 1: Seventy sex-year-old lady with background of hypothyroidism, hypertension and alcohol excess presented with acute onset of confusion. Her admission Sodium [Na+] level was 117 mmol/l and represented an acute drop f...

Postoperative hypocalcaemia is usually transient; we present a case report of persistent symptomatic hypocalcaemia following elective thyroid surgery; its challenging pharmaceutical management including the successful use of a novel therapeutic agent. A 56 yr old woman with known type 2 diabetes, morbid obesity (treated with gastric band), and benign intracranial hypertension underwent total thyroidectomy for a multi-nodular goitre, following which she became symptomatic with ...

Background: Iodine-131 (I-131) has been used to treat hyperthyroidism for half a century. Recent recommendations from the RCP London and British Thyroid Association suggest 400 MBq in most cases, but 500–600 MBq for toxic multinodular goitre (MNG). We have reviewed our clinic data with particular reference to response to a standard dose, 400 MBq, given to treat hyperthyroidism.Method: Casenotes of 88 patients who received 400 MBq I-131 for hyperthyr...

A 37 year-old gentleman presented following an episode of dizziness while at work operating a fork-lift truck. There was no collapse or associated symptoms. He had been diagnosed with autoimmune hypothyroidism two months previously; commenced levothyroxine, currently at a dose of 75 micrograms daily; and lost ten kilograms in weight. On examination there were no signs of hypoadrenalism aside from a significant postural drop in blood pressure (lying 1...

A 37 year-old gentleman presented following an episode of dizziness while at work operating a fork-lift truck. There was no collapse or associated symptoms. He had been diagnosed with autoimmune hypothyroidism two months previously; commenced levothyroxine, currently at a dose of 75 micrograms daily; and lost ten kilograms in weight. On examination there were no signs of hypoadrenalism aside from a significant postural drop in blood pressure (lying 1...